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Berg, J.A., Zhou, Y., Ouyang, Y. et al. Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns. Nat Cell Biol 25, 616–625 (2023). https://doi.org/10.1038/s41556-023-01117-9
Introduction
Metabolism, which is all the chemical reactions in the body, is very important for our systems. It controls things like digestion, excretion, cell development and our response to stress. It’s a complex network, and it can be hard to understand the data related to it. To make it easier, scientists created Metaboverse, a tool that helps us to understand these complicated processes that happen inside our bodies. They used algorithms to find patterns in the data, despite us not having access to all the data.
What is Metaboverse?
Metaboverse is like a special website that takes information about genes, proteins, and molecules in our body and puts them together in a big database. It then uses smart algorithms to find interesting patterns and quickly figure out how different parts of our body work together to control important processes.
The tool lets you see and explore different reactions and their parts one by one. You can look at how they’re connected to other reactions in the body. It’s like having a map to understand how everything fits together in a simple way. Metaboverse can compare different reactions to see if there are any big changes happening. It gives you a list of reactions that have noticeable differences, like things going up or down by a certain amount. You can look through the list and see which reactions catch your attention.
Applications of Metaboverse
In a research study about chemical substances in the blood of lung cancer patients, Metaboverse discovered new patterns in how these substances work. One particular substance called “SMS” (somatostatin) was found to be connected to better chances of survival for lung cancer patients. This shows that Metaboverse has the ability to find important information that other tools might have missed, helping us better understand the biology of the disease.
Summary
Metaboverse outperformed other similar tools by consistently ranking relevant reactions higher and offering an intuitive format for exploring patterns, even with missing data.
Overall, Metaboverse is a helpful tool for researchers. It brings together different information from different sources. It helps researchers find patterns and connections in data related to the processes inside the body. By analyzing data from different organisms, Metaboverse allows researchers to identify potential trends. This can spark new theories and ideas about how different biological systems function.
Works Cited
Berg, Jordan A., et al. “Metaboverse.” GitHub, 1 Nov. 2021, github.com/Metaboverse/Metaboverse. Accessed 7 May 2023.
Kornberg, Hans. “Metabolism | Definition, Process, & Biology.” Encyclopædia Britannica, 7 Nov. 2018, http://www.britannica.com/science/metabolism.
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